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A number of clinical trials are currently underway to test whether glioblastoma virotherapy will facilitate antitumor efficacy, but research led by E. Antonio Chiocca, MD, PhD, chairman of the Department of Neurosurgery at Brigham and Women's Hospital, and published online on Nov. 25, 2012 in Nature Medicine, shows that in pre-clinical models.

Despite active research in virotherapy, this apparently safe modality has not achieved widespread success. The immune response to viral infection appears to be an essential factor that determines the efficacy of oncolytic viral therapy. The challenge is determining whether the viral-elicited immune response is a hindrance or a tool for viral treatment. NK cells are a key component of innate.

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The obvious inadequacy of conventional therapies to combat cancer has spawned the development of a variety of nonconventional treatment modalities such as cancer-specific replication competent.

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